Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro
نویسندگان
چکیده
منابع مشابه
N-cadherin attenuates nucleus pulposus cell senescence under high-magnitude compression
Mechanical compression is important in disc degeneration. N-cadherin (N-CDH)-mediated signaling contributes to the maintenance of the normal nucleus pulposus (NP) cell phenotype and NP matrix biosynthesis. Our preliminary study demonstrated that a high‑magnitude compression (20% deformation) promotes NP cell senescence in a three‑dimensional scaffold culture system. The aim of the present study...
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BACKGROUND Resveratrol, a component of red wine, has been reported to decrease prostaglandin E2 production by inhibiting the cyclooxygenase-2 cascade and to modulate various voltage-dependent ion channels, suggesting that resveratrol could attenuate inflammatory hyperalgesia. However, the effects of resveratrol on inflammation-induced hyperexcitability of nociceptive neurons in vivo remain to b...
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Oxidative stress induced disc cell apoptosis plays an important role in intervertebral disc (IVD) degeneration. The present study aims to investigate effects of resveratrol (RV), a natural polyphenol compound, on sodium nitroprusside (SNP) induced nucleus pulposus (NP) cell apoptosis and related mechanism. Rat NP cells were pretreated with RV, N-acetyl cysteine (NAC) and carboxy-PTIO (PTIO) bef...
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Copper sulfate-induced premature senescence (CuSO4-SIPS) consistently mimetized molecular mechanisms of replicative senescence, particularly at the endoplasmic reticulum proteostasis level. In fact, disruption of protein homeostasis has been associated to age-related cell/tissue dysfunction and human disorders susceptibility. Resveratrol is a polyphenolic compound with proved antiaging properti...
متن کاملSenescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
STUDY DESIGN Senescence-related markers were assessed in surgically obtained human nucleus pulposus (NP) specimens. PURPOSE To demonstrate the mechanism and signaling pathway involved in the senescence of NP chondrocytes. OVERVIEW OF LITERATURE The population of senescent disc cells has been shown to be increased in degenerated or herniated discs. However, the mechanism and signaling pathwa...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2019
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20190126